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Retrieved from Wharton-a, S., Aronne, L

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A recent study 170 demonstrated that triptolide at low concentrations (50 nmolL 1 ) had an anti-inflammatory effect in human IVD cells by suppressing the expression of IL-6/-8, PGE2S, MMP1/2/3/13, and TLR2/4 and an anticatabolic effect on the production of aggrecan and collagen-II

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The activation of neutrophils in ALD is primarily driven by toxic metabolic byproducts of alcohol metabolism and oxidative stress responses [45, 77, 78]